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Brian G Rowan Selected Research

tirbanibulin

11/2017Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression.
9/2012Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts.
4/2012KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.

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Brian G Rowan Research Topics

Disease

31Breast Neoplasms (Breast Cancer)
01/2021 - 01/2004
26Neoplasms (Cancer)
01/2020 - 06/2003
7Neoplasm Metastasis (Metastasis)
01/2021 - 01/2004
5Prostatic Neoplasms (Prostate Cancer)
03/2016 - 07/2010
5Adenocarcinoma
05/2012 - 01/2004
4Triple Negative Breast Neoplasms
01/2020 - 01/2012
4Carcinogenesis
09/2016 - 06/2010
4Endometrial Neoplasms (Endometrial Cancer)
08/2005 - 01/2004
3Inflammation (Inflammations)
03/2016 - 11/2013
2Disease Progression
09/2016 - 01/2012
2Ovarian Neoplasms (Ovarian Cancer)
12/2015 - 02/2013
2Obesity
11/2013 - 02/2012
2Carcinoma (Carcinomatosis)
01/2004 - 06/2003
1Chondrosarcoma
01/2021
1Virus Diseases (Viral Diseases)
01/2021
1Osteosarcoma (Osteogenic Sarcoma)
01/2021
1COVID-19
01/2020
1Body Weight (Weight, Body)
11/2017
1Hyperinsulinism (Hyperinsulinemia)
03/2016
1Autoimmune Diseases (Autoimmune Disease)
03/2016
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2016
1Neoplasm Micrometastasis
01/2016
1Fibrosis (Cirrhosis)
12/2013
1Thyroid Neoplasms (Thyroid Cancer)
10/2013
1Prostatic Intraepithelial Neoplasia
05/2012

Drug/Important Bio-Agent (IBA)

14TamoxifenFDA LinkGeneric
11/2017 - 06/2003
13Estrogen Receptor alphaIBA
09/2016 - 01/2004
12Estrogen ReceptorsIBA
11/2017 - 06/2003
9Estrogens (Estrogen)FDA Link
09/2016 - 03/2005
8Proteins (Proteins, Gene)FDA Link
09/2016 - 01/2004
7src-Family KinasesIBA
11/2017 - 01/2004
5Estradiol (Delestrogen)FDA LinkGeneric
12/2015 - 04/2004
5methylselenic acidIBA
01/2012 - 08/2005
4LigandsIBA
01/2012 - 11/2006
4AntibodiesIBA
12/2009 - 01/2004
3Pharmaceutical PreparationsIBA
01/2021 - 04/2012
3tirbanibulinIBA
11/2017 - 04/2012
3VimentinIBA
11/2017 - 01/2012
3Interleukin-17 (Interleukin 17)IBA
03/2016 - 05/2012
3Phosphotransferases (Kinase)IBA
12/2015 - 01/2004
3ParaffinIBA
01/2014 - 12/2009
3SeleniumIBA
01/2012 - 08/2005
3Hormones (Hormone)IBA
01/2012 - 01/2009
3Biomarkers (Surrogate Marker)IBA
01/2012 - 07/2010
2matrigelIBA
01/2021 - 01/2012
2Cyclin D1IBA
11/2017 - 11/2009
2ChromatinIBA
11/2017 - 12/2015
2PeptidomimeticsIBA
11/2017 - 09/2012
2CateninsIBA
11/2017 - 01/2012
2Peptides (Polypeptides)IBA
11/2017 - 04/2012
2Cadherins (E-Cadherin)IBA
11/2017 - 01/2012
2Protein Isoforms (Isoforms)IBA
09/2016 - 12/2009
2Interleukin-17 ReceptorsIBA
03/2016 - 05/2012
2Insulin (Novolin)FDA Link
03/2016 - 11/2013
2DNA (Deoxyribonucleic Acid)IBA
01/2016 - 01/2014
2Interleukin-8 (Interleukin 8)IBA
01/2016 - 01/2014
2MelatoninIBA
08/2014 - 11/2013
2Estrogen Receptor Modulators (Antiestrogen)IBA
08/2014 - 06/2003
2ProgesteroneFDA LinkGeneric
02/2013 - 01/2004
2Paclitaxel (Taxol)FDA LinkGeneric
09/2012 - 01/2012
2CaspasesIBA
04/2012 - 09/2008
2AndrogensIBA
02/2012 - 07/2010
2Progesterone Receptors (Progesterone Receptor)IBA
01/2012 - 06/2010
2Selenium CompoundsIBA
11/2009 - 08/2005
2afimoxifene (hydroxytamoxifen)IBA
11/2006 - 08/2005
2Messenger RNA (mRNA)IBA
11/2006 - 01/2004
2Selective Estrogen Receptor Modulators (SERM)IBA
03/2005 - 04/2004
1HydrogelsIBA
01/2021
1Parathyroid Hormone-Related ProteinIBA
01/2021
1LuciferinsIBA
01/2021
1Parathyroid Hormone (Parathormone)IBA
01/2021
1Biocompatible Materials (Biomaterials)IBA
01/2021
1Mitogen-Activated Protein KinasesIBA
01/2020
1Hypochlorous Acid (Hypochlorite)IBA
01/2020
1Disinfectants (Biocides)IBA
01/2020
1RNA Polymerase II (RNA Polymerase B)IBA
11/2017
1hydrogen sulfite (bisulfite)IBA
11/2017
1Histones (Histone)IBA
11/2017
1MicroRNAs (MicroRNA)IBA
09/2016
1Phenobarbital (Luminal)FDA Link
09/2016
1Glycogen Synthase KinasesIBA
03/2016
1Proteasome Endopeptidase Complex (Proteasome)IBA
03/2016
1Glycogen Synthase Kinase 3IBA
03/2016
1Matrix Metalloproteinases (MMPs)IBA
01/2016
1Green Fluorescent ProteinsIBA
01/2016
1Conditioned Culture MediaIBA
01/2016
1Tyrosine (L-Tyrosine)FDA Link
08/2014
1PanobinostatIBA
06/2014
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2014
1CytokinesIBA
12/2013
1Insulin-Like PeptidesIBA
11/2013
1Interleukin-6 (Interleukin 6)IBA
11/2013
1EnzymesIBA
02/2013
1Staphylococcal Protein A (Protein A)IBA
02/2013
1Transcription Factors (Transcription Factor)IBA
02/2013
1Focal Adhesion Protein-Tyrosine KinasesIBA
09/2012

Therapy/Procedure

19Therapeutics
01/2020 - 04/2004
3Chemoprevention
02/2012 - 08/2005
1Drug Therapy (Chemotherapy)
10/2013